What does science say about medium chain triglycerides?

26 Scientific studies on MCT oil

Scientific research attributes several health benefits to MCT oil and the way these medium chain fatty acids are processed by the body. We used 26 studies in this MCT file knowing that many more studies have been conducted with MCTs.

On Google Scholar, I find 30,000 studies where Medium chain Triglycerides are listed. At the National Library of Medicine (PubMed) I find 6767 research results on MCT.

1. Eur J Clin Nutr. 2014 Oct; 68(10): 1134–1140. , Published online 2014 Jul 30. doi: 10.1038/ejcn.2014.145,; PMID: 25074387, Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Marie-Pierre St-Onge,1,2 Brian Mayrsohn,1 Majella O’Keeffe,1,2 Harry R. Kissileff,1,2 Arindam Roy Choudhury,3 and Blandine Laferrère2

2. Physiology & Behavior, Volume 179, 1 October 2017, Pages 422-426 Coconut oil has less satiating properties than medium chain triglyceride oil. Author links open overlay panelR.Kinsella T.Maher M.E.Clegg

3. J Am Coll Nutr. Author manuscript; available in PMC 2010 May 21. Published in final edited form as: J Am Coll Nutr. 2008 Oct; 27(5): 547–552. PMCID: PMC2874191, NIHMSID: NIHMS201754, PMID: 18845704 4. . 2003 Dec;27(12):1565-71. , doi: 10.1038/sj.ijo.0802467. Greater Rise in Fat Oxidation With Medium-Chain Triglyceride Consumption Relative to Long-Chain Triglyceride Is Associated With Lower Initial Body Weight and Greater Loss of Subcutaneous Adipose Tissue M-P St-Onge 1 , P J H Jones

5. . 1982 Apr;35(4):678-82. , doi: 10.1093/ajcn/35.4.678. Enhanced Thermogenesis and Diminished Deposition of Fat in Response to Overfeeding With Diet Containing Medium Chain Triglyceride N Baba, E F Bracco, S A Hashim

6. Clinical Trial, . 1996 Mar;50(3):152-8. , Twenty-four-hour Energy Expenditure and Urinary Catecholamines of Humans Consuming Low-To-Moderate Amounts of Medium-Chain Triglycerides: A Dose-Response Study in a Human Respiratory Chamber , A G Dulloo 1 , M Fathi, N Mensi, L Girardier

7. J Am Coll Nutr. Author manuscript; available in PMC 2010 May 21., J Am Coll Nutr. 2008 Oct; 27(5): 547–552. Medium Chain Triglyceride Oil Consumption as Part of a Weight Loss Diet Does Not Lead to an Adverse Metabolic Profile When Compared to Olive Oil, Marie-Pierre St-Onge, PhD, Aubrey Bosarge, BA, Laura Lee T. Goree, RD, MSc, and Betty Darnell, RD

8. Clinical Trial, . 2009 Apr;55(2):120-5. , doi: 10.3177/jnsv.55.120. , Effect of Ingestion of Medium-Chain Triacylglycerols on Moderate- And High-Intensity Exercise in Recreational Athletes , Naohisa Nosaka 1 , Yoshie Suzuki, Akira Nagatoishi, Michio Kasai, Jian Wu, Motoko Taguchi

9. . 2016 May 12;8(5):281. , doi: 10.3390/nu8050281. , Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals , Sabri Ahmed Rial 1 , Antony D Karelis 2 , Karl-F Bergeron 3 , Catherine Mounier 4

10. . 2013 Dec;16(12):1079-85., doi: 10.1089/jmf.2012.0303. , Antimicrobial Effects of Virgin Coconut Oil and Its Medium-Chain Fatty Acids on Clostridium Difficile , Michael Shilling 1 , Laurie Matt, Evelyn Rubin, Mark Paul Visitacion, Nairmeen A Haller, Scott F Grey, Christopher J Woolverton

11. toxicology in vitre, 10,2015, Immune activation by medium-chain triglyceride-containing lipid emulsions is not modulated by n-3 lipids or toll-like receptor 4, Author links open overlay panelEvelyn D.Olthof a Alexandra F.Gülich a Mike F.Renne a b SijaLandman a c

12. . 2007 Jun;10(2):384-7., doi: 10.1089/jmf.2006.1209. , In Vitro Antimicrobial Properties of Coconut Oil on Candida Species in Ibadan, Nigeria , D O Ogbolu 1 , A A Oni, O A Daini, A P Oloko

13. . 2013 Dec;16(12):1079-85. , doi: 10.1089/jmf.2012.0303. , Antimicrobial Effects of Virgin Coconut Oil and Its Medium-Chain Fatty Acids on Clostridium Difficile , Michael Shilling 1 , Laurie Matt, Evelyn Rubin, Mark Paul Visitacion, Nairmeen A Haller, Scott F Grey, Christopher J Woolverton

14. . 2003 Jun;133(6):1815-20. , doi: 10.1093/jn/133.6.1815. , Consumption of a Functional Oil Rich in Phytosterols and Medium-Chain Triglyceride Oil Improves Plasma Lipid Profiles in Men , Marie-Pierre St-Onge 1 , Benoît Lamarche, Jean-François Mauger, Peter J H Jones

15. . 2016 Feb;28:91-102. , doi: 10.1016/j.jnutbio.2015.10.005. Epub 2015 Oct 26., Medium-chain Triglycerides and Monounsaturated Fatty Acids Potentiate the Beneficial Effects of Fish Oil on Selected Cardiovascular Risk Factors in Rats , Vijay Kumar Reddy Kondreddy 1 , Maheswaraiah Anikisetty 1 , Kamatham Akhilender Naidu 2

16. . 2007 Jul;56(7):985-91. , doi: 10.1016/j.metabol.2007.03.005. , Effects of Dietary Medium-Chain Triglyceride on Weight Loss and Insulin Sensitivity in a Group of Moderately Overweight Free-Living Type 2 Diabetic Chinese Subjects , Jian Rong Han 1 , Bin Deng, Jing Sun, Chao Gang Chen, Barbara E Corkey, James L Kirkland, Jing Ma, Wen Guo

17. . 1992 May;41(5):641-7. , Dietary Substitution of Medium-Chain Triglycerides Improves Insulin-Mediated Glucose Metabolism in NIDDM Subjects , R H Eckel 1 , A S Hanson, A Y Chen, J N Berman, T J Yost, E P Brass

18. . 2007 Jul;56(7):985-91. , doi: 10.1016/j.metabol.2007.03.005. , Effects of Dietary Medium-Chain Triglyceride on Weight Loss and Insulin Sensitivity in a Group of Moderately Overweight Free-Living Type 2 Diabetic Chinese Subjects , Jian Rong Han 1 , Bin Deng, Jing Sun, Chao Gang Chen, Barbara E Corkey, James L Kirkland, Jing Ma, Wen Guo

19. The lancet neurology, Volume 17, Issue 1, January 2018, Pages 84-93, Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders, Author links open overlay panelKatrinAugustinBSc a AzizaKhabbushMSc b SophieWilliamsPhD c SimonEatonPhD b MichaelOrfordPhD b ProfJ HelenCrossPhD d ProfSimon J RHealesPhD b †ProfMatthew CWalkerPhD c †ProfRobin S BwilliamsPhD a †

20; . Neuropharmacology. 2013 Jun; 69: 105–114. , doi: 10.1016/j.neuropharm.2012.11.004, Seizure control by ketogenic diet-associated medium chain fatty acids Pishan Chang,a Nicole Terbach,a Nick Plant,b Philip E. Chen,a Matthew C. Walker,c,∗∗ and Robin S.B. Williamsa,∗

21. . 2016 Feb;139(Pt 2):431-43. , doi: 10.1093/brain/awv325. Epub 2015 Nov 25. , Seizure Control by Decanoic Acid Through Direct AMPA Receptor Inhibition , Pishan Chang 1 , Katrin Augustin 1 , Kim Boddum 2 , Sophie Williams 2 , Min Sun 2 , John A Terschak 3 , Jörg D Hardege 3 , Philip E Chen 1 , Matthew C Walker 4 , Robin S B Williams

22. annals of the new york academy of science, Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease , Stephen C. Cunnane , Alexandre Courchesne‐Loyer , Valérie St‐Pierre , Camille Vandenberghe , Tyl er Pierotti ,Mélanie Fortier ,Etienne Croteau , Christian‐Alexandre, Castellano

23. . 2004 Mar;25(3):311-4. , doi: 10.1016/S0197-4580(03)00087-3. , Effects of Beta-Hydroxybutyrate on Cognition in Memory-Impaired Adults , Mark A Reger 1 , Samuel T Henderson, Cathy Hale, Brenna Cholerton, Laura D Baker, G S Watson, Karen Hyde, Darla Chapman, Suzanne Craft

24. Physiology & Behavior , Volume 188, 1 May 2018, Pages 205-211, A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder, Ryan W.Y.Lee a b c Michael .Corley e AlinaPang e GayeArakaki f LisaAbbott c MichaelNishimoto a RobMiyamoto c EricaLee e SusanYamamoto c Alika K.Maunakea e AnnetteLum-Jones e MikiWong c d

25. Front Mol neuroscience, . 2017; 10: 34. , Published online 2017 Feb 21. doi: 10.3389/fnmol.2017.00034, Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches , Ning Cheng,1,* Jong M. Rho,1,2,3 and Susan A. Masino4

26. . 2019 Mar;22(2):129-134. , The Emerging Role of Ketogenic Diets in Cancer Treatment , Rainer Johannes Klement 1

Bart Maes