Bart Maes

Several articles on polyphenols and olive leaf extract. Written by Bart Maes. The organic veggie man. His articles always have a strong scientific background. No nonsense and no chicken talk.

Special thanks to: Professor Benlemlih M, Dr. Ghanam J and Professor H. Joyeux. In their work Polyphenols in olive oil, plants and olive leaf extracts, invaluable for health

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Beauchamp GK, Russell SJK, Diane M., Jianming L., Jana P., Qiang H., et al. Phytochemistry: Ibuprofenlike activity in extravirgin olive oil. Nature 2005 ; 437 : 45–46.
Berglin E., Kokkonen H., Einarsdottir E., Agren A., Rantapaa Dahlqvist S., Influence of female hormonal factors, in relation
to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden : a case-control study. scan. J. Rheumatol. 2010 ; 39 :454-60.
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Camargo A., Rangel-Zuniga O., Haro C., Meza- Miranda E., Pena-Orihuela P., Meneses M., et al. Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels. food chem. 2014 ; 162 : 161-171.
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Covas MI, de la Torre K., Farre-Albaladejo M., Kaikkonen J., Fito M., Lopez-Sabater C., et al. Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in human. Free Radic. bio. med. 2006 ; 40 : 608–16.
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Estruch, R., Martinez-Gonzalez, MA, Corella, D., Salas-Salvado J, RuizGutierrez V, Covas MI, et al. Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors: A Randomized Trial. Ann. Internal. med. 2006 ; 145: 1-11.
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001 ; 285 : 2486-2497.
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Fito M, Cladellas M, Torre R, Marti J, Munoz D, Schroder H, et al., Anti-inflammatory effect of virgin olive oil in stable coronary disease patients : a randomized, crossover, controlled trial. EUR. J. Clin. Nutr. 2007 ; 62 : 570–574.
Fortes C, Garcia-Vilas J, Quesada A, Medina M. Evaluation of the anti-angiogenic potential of hydroxytyrosol and tyrosol, two bio-active phenolic compounds of extra virgin olive oil, in endothelial cell cultures. food chem. 2012 ; 134 : 134–140.
Giner E, Andujar I, Recio M, Rios J, Cerda-Nicolas J, Giner R. Oleuropein ameliorates acute colitis in mice. J. Agric. food Chem. 2011 ; 59: 12882–92.
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Lu B, Hiraki L, Sparks JA, Malspeis S, Chen CY, Awosogba JA, et al . Being overweight or obese and risk of developing rheumatoid arthritis among women : a prospective cohort study. Ann. rheumatism. this. 2014 ; 73: 205-459.
Maiuri M, Stefano D, Meglio P, Irace C, Savarese M, Sacchi R, et al. Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation. Naunyn Schmiedebergs Arc.h Pharmacol. 2005 ; 371: 457-465.
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Richard N, Arnold S, Hoeller U, Kilpert C, Wertz K, Schwager J. Hydroxytyrosol Is the Major Anti-Inflammatory Compound in Aqueous Olive Extracts and Impairs Cytokine and Chemokine Production in Macrophages. Planta Medica 2011 ; 77 : 1890-1897.
Rosignoli P, Fuccelli R, Fabiani R, Servili M, Morozzi G. Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes. J. Nutr. biochem. 2013 ; 24:1513-1519.
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Sanchez-Fidalgo S, Sanchez de Ibarguen L, Cardeno A, Alarcon de la Lastra C. Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model. EUR. J. Nutr. 2011 ; 51 : 497–506.
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St-Laurent-Thibault C, Arseneault M, Longpre F, Ramassamy C. Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-b-induced toxicity. Involvement of the NF-κβ signaling. curr. Alzheimer’s Res. 2011 ; 8 : 543–551.
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isioli F, Galli C, Bornet F, Mattei A, Patelli R, Galli G, et al. Olive oil phenolics are dose- dependently absorbed in humans. FEBS Lett. 2000 ; 468 :159–160.
Visioli F, Galli C, Grande S, Colonnelli K, Patelli C, Galli G, et al . Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration. J. Nutr. 2003 ; 133 : 2612–2615.
Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J, et al. Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann. rheumatism. This . 2009 ; 68 : 954–60.
Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, et al . Gutresiding segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010 ; 32: 815-827.
Zhang X, Cao J, Jiang L, Zhong L. Suppressive effects of hydroxytyrosol on oxidative stress and nuclear Factor-kappa activation in THP‐1 cells. bio. pharm. bull. 2009a ; 32 : 578–582.
Zhang X, Cao J, Zhong L. Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. Naunyn Schmiedebergs Arch. Pharmacol. 2009B ; 379 : 581–6.
Markin D, Duek L, Berdicevsky I, “In vitro antimicrobial activity of olive leaves”, Mycoses, Volume 46, Issue 3-4, pages 132–136, March 2003
Serafini M, Laranjinha JA, Almeida LM, Maiani G, “Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their impact on plasma total antioxidant capacity in humans”, Journal Nutr. Biochem, Issue 11 pages 585-590, 2000
Khayyal MT et al., “Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats” Arzneimittelforschung 52(11):797-802, 2002
Manna C, Migliardi V, Gollino P, SCognamiglio A, Galletti P, Chiariello M, Zoppia V. ,“Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion” Journal Nutr Biochem, Aug 2004;15(8):461-6 , 2004
Bao J, Zhang DW, Zhang JZ, Huang PL, Lee-Huang S, “Computational study of bindings of olive leaf extract (OLE) to HIV-1 fusion protein gp41.” FEBS Lett. 2007 Jun 12;581(14):2737-42. Epub 2007 May 21
Jemai H. et al., “Lipid-lowering and antioxidant effects of hydroxytyrosol and its triacetylated derivative recovered from olive tree leaves in cholesterol-fed rats, Journal Agric Food Chem. Issue 56(8):2630-6, 2008
Yamada K, Ogawa H, Hara A, Yoshida Y, et al, “Mechanism of the antiviral effect of hydroxytyrosol on influenza A virus including H1N1, H3N2, H5N1, H9N2” Antiviral Res. 2009 Jul;83(1):35-44. doi: 10.116/j.antiviral.2009.03.002. Epub 2009 Mar 24
Jemai H. et al., “Antidiabetic and Antioxidant Effects of Hydroxytyrosol and Oleuropein from Olive Leaves in Alloxan-Diabetic Rats” J Agric Food Chem, 2009 Oct 14;57(19):8798-804
Vlassios Goulas, Vassiliki Exarchou Anastassios N. Troganis Eleni Psomiadouet al, “Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells”, Molecular Nutrition & Food Research, Volume 53, Issue 5, Pages 600-608, 2009
Poudyal H. Et al., “Olive Leaf Extract Attenuates Cardiac, Hepatic, and Metabolic Changes in High Carbohydrate-, High Fat-Fed Rats” J Nutr. 2010
J. Munoz-Marin et al, “Cytoprotective effect of hydroxytyrosyl alkyl ether derivatives after oral administration to rats in a model of glucose-oxygen deprivation in brain slices.”, Journal of Agricolture Food Chem. 60(31):7659-64, 2012
Castaner O. et al. “Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans”, Journal Clin Nutr. 2012 Mar 21
M. Kostomoiri, A. Fragkuoli, M. Sagnou et at, “Oleuropein, an Anti-oxidant Polyphenol Constituent of Olive Promotes -Secretase Cleavage of the Amyloid Precursor Protein”, Cell Mol Neurobiol., 33(1): 147-54 , 2013.

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